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What Is Pain?

Pain may seem simple, but it’s much more complex than you may realize. Dive into the 21st-century science of pain as we understand it and see how physicians approach both diagnosis and treatment.
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Rated 5 out of 5 by from Valuable Information for an Important Topic Everybody must deal with pain and this short course (12 lectures) provides a surprising amount of important information in dealing with pain. Thus, the combination of the importance of this topic and the quality of this presentation warrants the highest rating for this course. Dr. Griffith has structured this course in a logical manner that helps us follow this complicated topic. It shows how pain is sensed, what are the different kinds of pain, and how men and women sense pain differently, among many topics. I learned that what I thought was pain is actually nociception, not pain, and I learned why that is important. I learned that visceral pain such as hunger is fundamentally different from somatic pain such pinching my arm. Dr. Griffith shows how all this affects strategies for treating pain. Maybe it’s just me, but I thought that it took Dr. Griffith several lectures to get used to speaking to the camera. If so, I urge patience because she does get better. This course uses a lot of technical terminology which, in turn, creates a challenge in absorbing the material. I found that following along in the course guidebook during the lectures to be more beneficial in this course than in any other course. Of course, this makes it challenging to follow this course in audio format such as when driving or exercising. The course was published in 2026. My rating system: 5 Stars – Every TGC customer should take this course 4 Stars – Recommended 3 Stars – Go ahead and take it 2 Stars – Not recommended 1 Stars – Yuck
Date published: 2026-03-02
Rated 5 out of 5 by from OUTSTANDING ! GC+ at its best. Technical enough to be informative, but accessible for the scientifically literate general user. Motivated learners will use this course as a basis for further independent studies. I believe this course could be especially useful to a young person who is reflecting on career choices: it can go far in stimulating an interest in the sciences and healthcare. Some important and interesting issues in ethics are also addressed, as are philosophical questions regarding consciousness, human nature, and, how we encounter reality and interpret experiences. Emotional and psychological aspects of pain are included along with comprehensive explanations of the cellular, anatomical, physiological and genetic aspects.
Date published: 2026-03-01
Rated 5 out of 5 by from Great and clear overview of how pain works This course explains clearly how pain works in the body. She give in-depth but understandable explanations. Thank you!
Date published: 2026-02-27
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What Is Pain?

Trailer

What Is Pain and Why Do We Feel It?

01: What Is Pain and Why Do We Feel It?

You might be surprised to discover that the scientific definition of pain includes two specific and equal components—physiological and psychological. Learn about nociception, the three-step sensory process providing electrical signals to the brain from a noxious stimulus, such as a bee sting or toe stub. But is it pain? That’s for your brain to “decide.”

26 min
The Molecules, Cells, and Circuits of Pain

02: The Molecules, Cells, and Circuits of Pain

Explore the process of nociception at its three main levels of organization—the molecular level where specific pain proteins are stimulated, the cellular level where nociceptors generate electrical signals, and the circuit level where nociceptors make connections with neurons in the spinal cord. Learn about the many different types of nociceptors and the significant difference between reflexive and relay circuits.

30 min
Pain, Chronic Pain, and Headaches

03: Pain, Chronic Pain, and Headaches

Explore the distributed network of the many brain regions activated during the perception of pain. But what’s happening with the 85% of people with chronic back pain who have no physical cause for the pain? Could the brain itself be the problem? And given that the brain does not contain nociceptors, what causes the severe pain of headaches?

31 min
How Your Mental States Can Affect Pain

04: How Your Mental States Can Affect Pain

If you burn your finger, nociceptors begin the process that alerts your brain to tissue damage. But how your brain responds to those signals depends on your mental state. Learn how your attention, emotions, mindset, fatigue, expectations, beliefs, social context, and even hunger and thirst can all significantly influence your perception of pain. Explore several powerful psychological strategies that can alter your emotional response to pain.

31 min
Your Endogenous Opioid System

05: Your Endogenous Opioid System

Explore the endogenous opioid system, a complex network that plays a crucial role in modulating pain, pleasure, and overall well-being. Learn about the different types of neurotransmitters—including endorphins, enkephalins, and dynorphins—and neurotransmitter receptors spread out across our nervous system, influencing everything from pain perception to mood regulation. Discover why dysregulation of this system has been implicated in many medical conditions.

34 min
Do Animals Feel Pain?

06: Do Animals Feel Pain?

While every living organism can react to aversive stimuli, to what extent do animals experience pain as humans have defined it? Learn about experiments scientists have undertaken with a wide variety of animals to try to answer that complex question. From the flatworm to the zebrafish to the octopus, we do see animals with certain aspects of our own pain processing systems. But any conclusions about animal pain are inherently speculative—for now.

35 min
Neuropathic Pain

07: Neuropathic Pain

The neurological system that processes signals and interprets pain keeps us alive. But what happens when the system itself is damaged? Explore the many dimensions of neuropathic pain and learn how it can result from diabetes, chemotherapy, direct nerve injuries, or multiple sclerosis. Learn about some of the most common forms of chronic neuropathic pain, the peripheral neuropathies, as well as neuropathic facial pain.

31 min
Inflammation, Pain, and Gender Differences

08: Inflammation, Pain, and Gender Differences

Learn about inflammatory pain—with arthritis being the most well-known—and how it differs from neuropathic pain. Explore how the immune and nervous systems constantly influence each other and play a role in chronic conditions like autoimmune diseases and some neurological diseases. You’ll also learn about microglia, immune cells of the brain and spinal cord, and the role they play in pain perception—very differently for males than females.

32 min
Pain Originating from within Our Bodies

09: Pain Originating from within Our Bodies

At any given moment, about 25% of the adult population is experiencing visceral pain. And yet, the diagnosis and treatment of chronic visceral pain is often extremely difficult—at least for now. Learn about the differences between the body’s processing of internal versus external pain and explore the enteric nervous system—sometimes called our “second brain”—an essential system that can handle many complex tasks without any direct input from the brain or spinal cord.

34 min
The Genetics of Pain

10: The Genetics of Pain

While all humans have 99.9% of the same genes, what makes us unique is the expression of those genes. Discover the phenomenon of epigenetics—an important regulator of gene expression—and the role it plays in the variation of pain perception and tolerance between individuals. Also, explore what happens when genes that encode important pain proteins mutate and how that can affect pain tolerance.

33 min
What Itch Can Tell Us about Pain

11: What Itch Can Tell Us about Pain

If you’ve ever suffered from a serious itch—formally known as pruritus—you know why it’s often called pain’s close cousin and is considered one of the most bothersome bodily sensations. Learn about the theory of population coding and what it tells us about the neurological relationship between pain and itch, as well as why you might very well want to put an ice cube on that itchy insect bite.

33 min
Different Approaches to Pain Management

12: Different Approaches to Pain Management

Recent history has proven that relying on pharmaceuticals alone for pain management can have devastating consequences. While opioids still have a place in treating acute pain, it is clear that new approaches are necessary. Learn about the first new class of medication that has been approved by the FDA in more than two decades, the latest non-invasive electrical therapies for chronic pain, and the behavioral strategies that can bring relief for both acute and chronic pain.

38 min

Overview Course No. 10640

Are you in any pain right now? If so, can you point to the location of your pain? And how would you describe your pain level on a scale from one to 10?

Those seem like questions anyone should be able to answer, right? But they’re more complicated than they seem. We’ve all experienced pain, but describing it to another person, even a healthcare worker, can be incredibly difficult. After all, pain can be a burning, stinging, stabbing, or scratching feeling. It can be aching, throbbing, cramping, or electric. It can be steady, pulsating, or come and go throughout the day. It can be localized to the joint of a finger, or it can be somewhere in your abdomen and feel impossible to pinpoint. Pain can feel like a level 10 one minute and an “I’m not sure, maybe a six” the next.

What Is Pain? explains precisely why these simple-sounding questions are so difficult for us to answer. In 12 fascinating lectures, Theanne Griffith, PhD, takes us far beneath our common misconceptions about pain all the way down to the molecular level. You’ll be surprised to learn exactly what’s happening when that hammer hits your finger or when inflammation in the gut causes you to double over.

Not too long ago, medical professionals thought pain was the result of tissue damage—pure and simple. The medical goal was to heal the tissue and subdue the pain. Given the knowledge of the day, that simplistic model made sense. But, today, we have a much more complex understanding of pain thanks to the sophisticated brain imagery of MRIs and PET scans, a deeper understanding of neurons and neurochemicals, discovery of the immune system’s relationship to pain, advances in genetics, and more.

As you’ll learn in this course, our bodies possess nociceptors, which are specialized sensory neurons that have evolved to detect potentially harmful stimuli. Located in the skin, muscles, joints, and even internal organs, the nociceptors are activated and send signals through the spinal cord to the brainstem and higher brain centers. But no matter what signals your nociceptors are sending, your brain determines your perception of pain. That’s because pain is a conscious experience that encompasses sensory, emotional, cognitive, and social components.

About

Theanne Griffith

Beneath our aversion to pain lies an inconvenient but important truth: It’s essential for survival.

INSTITUTION

University of California, Davis

Theanne Griffith is an Assistant Professor of Physiology and Membrane Biology at the University of California, Davis, and a Howard Hughes Medical Institute Freeman Hrabowski Scholar. She earned her PhD in Neuroscience from Northwestern University. She has received numerous awards for her research and science outreach, including the Science Educator Award from the Society for Neuroscience. She has appeared on the PBS series NOVA, NPR’s science podcast Short Wave, and other programs. She is also an award-winning author of 15 science-themed children’s books.

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